Repurposing ciclopirox
نویسندگان
چکیده
منابع مشابه
Toward Repurposing Ciclopirox as an Antibiotic against Drug-Resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae
Antibiotic-resistant infections caused by gram-negative bacteria are a major healthcare concern. Repurposing drugs circumvents the time and money limitations associated with developing new antimicrobial agents needed to combat these antibiotic-resistant infections. Here we identified the off-patent antifungal agent, ciclopirox, as a candidate to repurpose for antibiotic use. To test the efficac...
متن کاملCiclopirox protects mitochondria from hydrogen peroxide toxicity.
1 The mitochondrial respiratory chain produces reactive oxygen species (ROS) during normal electron transport. Despite producing ROS, mitochondria are vulnerable to oxidative stress. Mitochondrial dysfunction has been associated with many degenerative diseases, making it important to identify compounds that protect mitochondria from ROS-mediated toxicity. Here we report that ciclopirox (CPX) bl...
متن کاملRepurposing Learning Object Components
This paper presents an ontology-based framework for repurposing learning object components. Unlike the usual practice where learning object components are assembled manually, the proposed framework enables on-the-fly access and repurposing of learning object components. The framework supports two processes: the decomposition of learning objects into their components as well as the automatic ass...
متن کاملThe purpose of repurposing
The goal of developing drugs that act at a single target – the long-standing focus on discovering the 'magic bullet' – as enticing and enduring as it has been, has not proven to be a uniformly successful endeavor. Most complex disorders, including those not only in oncology but also in neurology and neuropsychiatry, whether in their initial stages or in their progression, are not mediated by a ...
متن کاملRepurposing Tecfidera for cancer
compound dimethyl fumarate (DMF) has been an approved drug in Europe for several decades as a therapeutic for psoriasis and relapsing-remitting multiple sclerosis (MS). More recently, the drug has been approved in The United States as an MS treatment (Tecfidera®). Upon ingestion, the drug is rapidly metabolized into the biologically active form of the agent, mono methyl fumarate (MMF); the biol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2018
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd.2018.189